By Derek Leroith (Eds.)

ISBN-10: 0762302925

ISBN-13: 9780762302925

Quantity 2 has concerned with facets of the pituitary gland either anterior (growth hormone and prolactin receptors, and GH motion) and posterior (vasopressin) pituitary. moreover, thyroid melanoma and steroidogenic enzymes and precocious puberty are lined. ultimately, the "hot themes" comprise leptin and development issue signaling.

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1994). Separate mutations at y222 and S =6 diminished ligand binding and abolished signal transduction, as measured both by stimulation of protein synthesis and by transcriptional activation of a transiently transfected c-fos promoter reporter gene. Mutations at G 223, E TM, and F 22s did not alter receptor function. Mutation of the YGEFS motif to the consensus WSEWS sequence produced a GH-R that was functionally similar to the wild type receptor. Although these studies do not prove that the WSXWS motif and its variant in the GH-R are involved in receptor dimerization, they do illustrate its importance for normal receptor function.

Chem. 268, 5376-5381. A. (1995). Prolactin receptor antagonists that inhibit the growth of breast cancer cell lines. J. Biol. Chem. 270, 13133-13137. , & Taniguschi, T. (1995). Activation of STAT5 by interleukin 2 requires a carboxy-terminal region of the interleukin 2 receptor 13chain but is not essential for the proliferative signal transmission. Proc. Natl. Acad. Sci. USA 92, 5482-5486. , & Billestrup, N. (1996). Identification of a growth hormone-responsive STAT5-binding element in the rat insulin 1 gene.

Expression of the extracellular domain of the rat liver prolactin receptor and its interaction with ovine prolactin. J. Biol. Chem. 268, 22347-22352. Y. (1994). Transcriptional regulation by the helix bundle peptide hormones: growth hormone, prolactin, and hematopoietic cytokines. Endocr. Rev. 15, 627-649. N. (1994). Signaling by the cytokine receptor superfamily. Just another kinase story. Trends Endocrinol. Metab. 5, 137-143. M. (1995). Jaks and STATs in signaling by the cytokine receptor superfamily.

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Advances in Molecular and Cellular Endocrinology by Derek Leroith (Eds.)

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